Connecticut Children’s is among the most active in the country for basic, clinical and translational research. Our nationally recognized gastroenterologists lead and collaborate on 32-IRB approved studies including NIH- and privately-funded digestive diseases research projects.


  • In 2012, Dr. Hyams, along with Lee “Ted” Denson, MD, from Cincinnati Children’s Hospital Medical Center, received a $10.4M NIH grant for the Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT) study.
  • As the hub of the Pediatric Inflammatory Bowel Disease Collaborative Research Group, a 30-member organization formed in 2002, Connecticut Children’s leads ongoing research on the natural history of more than 1,700 cases of newly diagnosed IBD in children, correlating disease behavior with genetic and immunological parameters.
  • Connecticut Children’s is the leader with seven pediatric IBD centers in North America, recruiting patients for a groundbreaking study on risk assessment in children newly diagnosed with Crohn’s disease. This study is funded by the Crohn’s and Colitis Foundation.
  • Francisco Sylvester, MD, directs the IBD translational laboratory in the department of immunology at the University of Connecticut School of Medicine. Dr. Sylvester along with Anthony Vella, PhD, and a team of post-doctoral fellows are investigating basic mechanisms underlying the inflammatory process in ulcerative colitis and Crohn’s disease.
  • Wael Sayej, MD, is investigating basic mechanisms
    of inflammation in eosinophilic esophagitis.