Physician-in-Chief

Infectious Diseases & Immunology


860.545.9490

Juan C. Salazar, MD, MPH

Education

Education: MD, Pontificia Universidad Javeriana, 1986
MPH, University of Minnesota Medical School, 1995
Residency: Pediatrics, University of Connecticut, Pediatrics, 1988-1992
Fellowship: Pediatric Infectious Diseases, University of Minnesota, 1992-1995

Board Certifications

Pediatrics
Pediatric Infectious Diseases

Faculty Appointment

Chair, Department of Pediatrics and Professor of Pediatrics, University of Connecticut School of Medicine

Expertise

Dr. Salazar is director of the Pediatric and Youth HIV Program and a professor in pediatrics at the University of Connecticut School of Medicine department of pediatrics, division of pediatric infectious diseases. He joined faculty at University of Connecticut in 1998. Dr. Salazar is a fellow of the American Academy of Pediatrics, member of the Infectious Diseases Society of America, the Pediatric Infectious Disease Society, the HIV Medical Association and the Hartford and Connecticut medical societies.

Dr. Salazar’s basic translational research interest includes the analysis of the immunologic interactions between syphilis and HIV and the pathogenesis of spirochetal diseases including Lyme disease. Dr. Salazar is NIH funded to conduct a translational study of syphilis in Colombia and to assess the role of the innate immune responses in humans to Borrelia burgdorferi, the causative agent of Lyme disease. He has been the principal investigator for a variety of pharmaceutical industry sponsored clinical trials, including childhood vaccines and antibiotics. He has authored and co-authored more than 60 papers and book chapters. Dr. Salazar graduated from Universidad Javeriana in Bogotá, Colombia in 1986. He completed his residency in pediatrics at the University of Connecticut in 1992 and a fellowship in pediatric infectious diseases at the University of Minnesota Medical School in 1995. He obtained a masters degree in public health/epidemiology from the University of Minnesota School of Public Health in 1995. Dr. Salazar obtained a career mentor K-23 award in 2002, with Dr. Radolf as his primary mentor.

Published Research

  • Cruz AR, Ramirez LG, Zuluaga AV, Pillay A, Abreu C, Valencia CA, La Vake C, Cervantes JL, Dunham-Ems S, Cartun R, Mavilio D, Radolf JD and Salazar JC*.  Immune Evasion and Recognition of the Syphilis Spirochete in Blood and Skin of Secondary Syphilis Patients: Two Immunologically Distinct Compartments, PLoS Negl Trop Dis 6(7): e1717, 2012.
     
  • Roehm CE, Salazar JC, Hagstrom and Valdez TA. Phoma and Acremonium invasive fungal rhinosinusitis in congenital acute lymphocytic leukemia and literature review.  Int J Pediatr Otorhinolaryngol.  Jul 18. [Epub ahead of print], 2012.
     
  • Anand A, Luthra A, Dunham-Ems S, Caimano M, Karanian C, LeDoyt M, Cruz AR, Salazar JC, and Radolf JD.  TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure".  Journal of Bacteriology, 194(9): 2331-2333, 2012.
     
  • Hawley KL, Olson CM, Jr., Iglesias-Pedraz JM, Navasa N, Cervantes JL, Caimano MJ, Izadi H, Ingalls RR, Pal U, Salazar JC, Radolf JD, Anguita J. CD14 Cooperates with Complement Receptor 3 to Mediate MyD88-Independent Phagocytosis of Borrelia burgdorferi. Proc Natl Acad Sci USA. 109(4):1228-32, 2012.
     
  • Desrosiers DC, Anand A, Luthra A, Dunham-Ems SM, Ledoyt M, Cummings MA, Eshghi A, Cameron CE, Cruz AR, Salazar JC, Caimano MJ, Radolf JD.  TP0326, a Treponema pallidum β-Barrel Assembly Machinery A (BamA) Ortholog and Rare Outer Membrane Protein.  Mol Microbiol. 80:1496-1515, 2011.
     
  • Stojanov S, Lapidus S, Chitkara P, Feder H, Salazar JC, Fleisher TA, Brown MR, Edwards KM, Ward MM, Colbert RA, Sun HW, Wood GM, Barham BK, Jones A, Aksentijevich I, Goldbach-Mansky R, Athreya B, Barron KS, Kastner DL.  PFAPA syndrome is a disorder of innate immune regulation and Th1 activation responsive to IL-1 blockade.  Apr 8. Proc Natl Acad Sci USA, 108: 7148-7153, 2011.
     
  • Cervantes JL, Dunham-Ems SM, La Vake CJ, Petzke MM, Sahay B, Sellati TJ, Radolf JD, Salazar JC*.  Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-β. Proc Natl Acad Sci. 108(9):3683-8, 2011.
     
  • Courter JD, Teevan CJ, Li MH, Girotto JE and Salazar JC*.  Role of tipranavir in treatment of patients with multidrug-resistant HIV.  Ther Clini Risk Manag.  6  431-441, 2010.
     
  • Cox DL, Luthra A, Dunham-Ems S, Desrosiers DC, Salazar JC, Caimano MJ, Radolf JD. Surface immunolabeling and consensus computational framework to identify candidate rare outer membrane proteins of Treponema pallidum. Infect Immun. 78(12):5178-94, 2010.
     
  • Desrosiers DC, Bearden SW, Mier I Jr, Abney J, Paulley JT, Fetherston JD, Salazar JC, Radolf JD, Perry RD. Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence. Infect Immun. 78(12):5163-5177, 2010.
     
  • Deville JG, Goldfarb J, Kaplan SL, Equils O, Huang DB, Ang JY, Salazar JC *. The use of linezolid in the treatment of paediatric patients with infections caused by enterococci including strains resistant to vancomycin. J Antimicrob Chemother. 65(10):2267-70, 2010.
     
  • Cruz AR, Pillay A, Zuluaga AV, Ramirez LG, Duque JE, Aristizabal GE, Fiel-Gan MD,Jaramillo R, Trujillo R, Valencia C, Jagodzinski L, Cox DL, Radolf JD, Salazar JC*.  Secondary syphilis in Cali, Colombia:  New concepts in disease pathogenesis.  PLoS Negl Trop Dis. May 18;4(5):e690, 2010.
     
  • Courter JD; Girotto JE, Lobato MN, Orcutt D; Burke M, Feder HM; Krause PJ, Cohen-Abbo A, Salazar JC*.  Intravenous streptomycin treatment for treatment of Mycobacterium tuberculosis meningitis in an infant. Pharmacotherapy 30(11): 481e-484e, 2010.
     
  • Feder Jr. HM and Salazar JC.  A clinical review of 105 patients with PFAPA (A periodic fever syndrome).  Acta Pediatrica, 99(2):178-84, 2010.
     
  • Kanev P, Salazar JC. Unusual CNS infection from a subtorcular dermal sinus.  Acta Paediatr. 99(4):627-9, 2010.