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Juan C. Salazar, MD, MPH, FAAP

Physician-in-Chief

Executive Vice President of Academic Affairs


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Practice Name Connecticut Children's Specialty Group
Education

Education: MD, Pontificia Universidad Javeriana, 1986
MPH, University of Minnesota Medical School, 1995
Residency: Pediatrics, University of Connecticut, Pediatrics, 1988-1992
Fellowship: Pediatric Infectious Diseases, University of Minnesota, 1992-1995

Board Certifications
  • Pediatrics
  • Pediatric Infectious Diseases
  • Faculty Appointment

    Chair, Department of Pediatrics and Professor of Pediatrics, University of Connecticut School of Medicine

    Clinical Expertise

    Dr. Salazar is Physician-in-Chief, Executive Vice President of Academic Affairs at the Medical Center. He is also the Director of the Pediatric and Youth HIV program at Connecticut Children’s and serves as Professor and Chair of the Department of Pediatrics at the UConn School of Medicine.

    Dr. Salazar has received several NIH and private Foundation grants to study Pediatric HIV, congenital syphilis and Lyme disease. Dr. Salazar and his colleagues at the Spirochetal Research laboratories at the University of Connecticut Health Center are actively studying the immune response of children and adults who become infected with the Lyme disease bacterium. He also collaborates with translational and clinical researchers in Southern China and in Cali, Colombia.

    Selected Publications
    • Trujillo, R, Cervantes, JL, Hawley K, Cruz AR, Babappor, S, Murphy, M, Dadras, SS, Salazar, JC. Inflammation and immune evasion coexist in Treponema pallidum–infected skin. JAAD Case Reports, Volume 4, Issue 5, June 2018, Pages 462–46

    • Kumar S, Caimano MJ, Anand A, Dey A, Hawley KL, LeDoyt ME, La Vake CJ, Cruz AR, Ramirez LG, Paštěková L, Bezsonova I, Šmajs D, Salazar JC, Radolf JD. Sequence Variation
      of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete. MBio. 2018 Jun 12;9(3). pii: e01006-18. doi: 10.1128/mBio.01006-18

    • Flores G, Salazar JC. Immigrant Latino Children and the Limits of Questionnaires in Capturing Adverse Childhood Events. Pediatrics. 2017 Oct 9. pii: e20172842. doi:
      10.1542/peds.2017-2842. [Epub ahead of print] PMID: 28993444

    • Hawley, K, Cruz, AR, Benjamin, S, La Vake, C, Le Doyt, M, Mandich, D, Fiel-Gann, M, Cervantes, JL, Ramirez LG, Radolf, JD and Salazar, JC. IFNγ enhances CD64 ediated
      phagocytosis of human syphilitic serum opsonized Treponema pallidum by human macrophages Front. Immunol., 05 October 2017 https://doi.org/10.3389/fimmu.2017.01227

    • Qiu, Z, Cervantes JL, Cicek BB, Mukherjee S, Venkatesh M, Maher LA, Salazar JC. Mani S and Khanna K. Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4. Sci. Rep. 6, 31936; doi: 10.1038/srep31936 (2016)

    • Seña AC, Zhnag XH, Li T, Zheng HP, Yang B, Yang LG, Salazar JC, Cohen MS, Moody A, Radolf JD and Tucker JD. A systematic review of serological outcomes after syphilis
      treatment in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy. BMC Infectious Diseases,
      September 2015.

    • Luthra A, Anand A, Hawley H, LeDoyt M, La Vake C, Caimano M, Cruz A, Salazar JC and Radolf JD. A homology model reveals novel structural features and an immunodominant
      surface loop/opsonic target in the Treponema pallidum BamA ortholog TP0326. J Bacteriol. 2015 Mar 30. pii: JB.00086-15. [Epub ahead of print]

    • Cervantes JL, Hawley KL, Benjamin SJ, Weinerman B, Luu SM, Salazar JC. Phagosomal TLR signaling upon Borrelia burgdorferi infection. Front Cell Infect Microbiol. 2014 May
      20;4:55. doi: 10.3389/fcimb.2014.00055. eCollection 2014. PMC4033037.

    • Libardo MD, Cervantes JL, Salazar JC, Angeles-Boza AM. Improved Bioactivity of Antimicrobial Peptides by Addition of Amino-Terminal Copper and Nickel (ATCUN) Binding
      Motifs. Chem Med Chem. 2014 Aug;9(8):1892-901. PubMed PMID: 24803240.

    • Salazar JC, Cahn P, Della Negra M, De Aquino MZ, Robinson PA, Jelaska A, Mikl J. Efficacy and safety of tipranavir coadministered with ritonavir in HIV-1-infected children and
      adolescents: 5 years of experience. Pediatr InfectDis J. 2014 Apr;33(4):396-400. PubMePMID:23995585.

    • Cruz AR, Castrillón MA, Minotta AY, Rubiano LC, Castaño MC, Salazar JC. Gestational and congenital syphilis epidemic in the colombian pacific coast Sex Transm Dis. 2013
      Oct;40(10):813-8. doi: 10.1097

    • Salazar JC, Cahn P, Negra MD, De Aquino MZ, Robinson PA, Jelaska A, Mikl J. Efficacy and Safety of Tipranavir Co-Administered with Ritonavir in HIV-1-Infected Children and
      Adolescents: 5 Years of Experience. Pediatr Infect Dis J. 2013 Aug 29. [Epub ahead of print]

    • Silver AC, Dunne DW, Zeiss CJ, Bockenstedt LK, Radolf JD, Salazar JC, Fikrig E. MyD88 Deficiency Markedly Worsens Tissue Inflammation and Bacterial Clearance in mice Infected with Treponema pallidum, the Agent of Syphilis. PLoS One. 2013 Aug 5;8(8):e71388. doi: 10.1371/journal.pone.0071388.

    • Cervantes JL, La Vake CJ, Weinerman B, Luu S, O’Connell C, Verardi PH, Salazar JC*. Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of
      human monocytes. J Leukoc Biol. 2013 Aug 1. [Epub ahead of print]

    • Clark RB, Cervantes JL, Maciejewski MW, Farrokhi V, Nemati R, Yao X, Anstadt E, Fujiwara M, Wright KT, Riddle C, La Vake CJ, Salazar JC, Finegold S, Nichols FC. Serine lipids of Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands. Infect Immun. 2013 Jul 8. [Epub ahead of print]

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