Anemia is defined as a clinically significant decrease in hemoglobin/hematocrit (Hgb/Hct) that may create health symptoms for the patient. Mild decreases in Hgb/Hct identified on screening lab tests may not be clinically significant; follow-up with the primary care provider that includes a repeat laboratory evaluation may be all that is needed. Persistent or clinically significant anemia requires further evaluation. There are numerous potential etiologies, including diseases specific to the red cell and/or bone marrow, or more systemic diseases such as inflammatory conditions and nutritional deficiencies. Thalassemia trait is the most common benign condition that may be related to chronic persistent anemia.
Main Guideline HgB Confirmed Low by CBC Algorithm Suspected Thalassemia Trait Algorithm