Neuroirritability is defined as persistent or recurrent episodes of pain behaviors which, after assessment and management of potential nociceptive sources, can most likely be attributed to abnormal signaling of the central nervous system. Neuroirritability is frequently associated with other comorbid conditions (e.g., prematurity, hypoxic brain injury, genetic syndromes, developmental and communication delays, autonomic storming), and is very unlikely to be seen in neurotypical children. Although neuroirritability can present at any time, patients most commonly present during the newborn period, at the onset of adolescence, or in relation to neurotrauma that may happen later in life. 

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These guidelines are intended solely for the use of healthcare professionals who are licensed to practice medicine. This material is not intended to replace professional medical judgment, prescribing information or consultation with a medical professional. Any health care provider using this material acknowledges full responsibility for the medical care and treatment of patients. All health care providers are solely responsible for confirming the accuracy, timeliness, completeness, appropriateness and helpfulness of this material and making all medical, diagnostic or prescription decisions.

For questions about the guidelines, CLASP [at] Connecticutchildrens.org (email the CLASP team).