Pathway Background and Objectives

Eating disorders are increasingly prevalent in pediatrics and represent a complex interaction between medical and psychiatric manifestations. The need for a standardized approach is critical, due to the high risk of the condition (eating disorders have the highest mortality of any psychiatric disorder), as well as the high variation in presentations, particularly among children. This standardized pathway was first developed at Connecticut Children’s in 2003 and has undergone multiple revisions since. It rests on the core principle that it is necessary to recognize the physiologic manifestations of restricted eating, as they are a reflection of true medical instability. Once the risk is identified, the pathway outlines a process of resuming adequate nutritional intake while watching for signs and symptoms of refeeding syndrome. It utilizes an incentive-based system, in which gradual increases in caloric intake occur within a restricted and highly structured setting, leading to gradual medical stability. This clinical pathway involves daily multi-disciplinary collaboration, with pediatric hospital medicine, psychiatry, nutrition, and cardiology specialists all playing an integral role in the care.

The objectives of this pathway are to:

  • Restart nutrition in safe manner to prevent refeeding syndrome
  • Promote patient weight gain and gradual medical stability in structured manner
  • Provide appropriate treatment for the patient’s medical needs AND begin to address underlying psychiatric causes

Algorithm  Educational Module


Patient Handouts

 English  Spanish

•    % Patients with pathway order set (ARFID/NON-ARFID)
•    AVG time (minutes) from hospital admission to pathway order set (ARFID/NON-ARFID)
•    % Patients who require NG placement (ARFID/NON-ARFID)
•    % Patients with 1 NG tube placement (ARFID/NON-ARFID)
•    % Patients with 2 NG tube placements (ARFID/NON-ARFID)
•    % Patients with > 2 NG tube placements (ARFID/NON-ARFID)
•    % Patients with Hypophosphatemia who receive phosphorus supplement (ARFID/NON-ARFID) 
•    AVG time (days) from hospital admission to Order Activity 5 (ARFID/NON-ARFID)
•    # Patients readmitted (ARFID/NON-ARFID)
•    ALOS (Days) (ARFID/NON-ARFID)
 

•    Amianto, Federico et al. Psychological Effects of Nasogastric Tube (NGT) in Patients with Anorexia Nervosa: A Systematic Review. Nutrients 2024, 16, 2316. https://doi.org/10.3390/nu16142316
•    The American Psychiatric Association Practice Guideline for the Treatment of Patients with Eating Disorders. Fourth Edition. Feb 2023. https://psychiatryonline.org/doi/book/10.1176/appi.books.9780890424865
•    Bern EM, et al. Variation in care for inpatients with avoidant restrictive food intake disorder leads to development of a novel inpatient clinical pathway to standardize care. J Eat Disord. 2024 May 23;12(1):66. PMID: 38783304; PMCID: PMC11112782. https://doi.org/10.1186/s40337-024-01018-8
•    Horovitz. Advancements in the Diagnosis and Treatment of Eating Disorders in Children and Adolescents: Challenges, Progress, and Future Directions. Review. Nutrients 2025, 17, 1744 https://doi.org/10.3390/nu17101744
•    Kaplan et al. Evaluation of an eating disorder screening and care pathway implementation in a general mental health private inpatient setting. Journal of Eating Disorders (2024) 12:119. https://doi.org/10.1186/s40337-024-01077-x
•    Krug et al. A meta-analysis of mortality rates in eating disorders: An update of the literature from 2010 to 2024.  Clinical Psychology Review. 116 (2025) 102547.  https://doi.org/10.1016/j.cpr.2025.102547
•    Rajagopalan, Aishwarya et al. Protocol-based Interventions for Inpatient Medical Stabilization of Anorexia Nervosa in Children and Adolescents. Psychiatric annals, 2025-11, Vol.55 (11), p.e262-e266
•    Riss et al.  A Bitter Pill: The Ethics of Involuntary Treatment of Adolescents With Severe Eating Disorders. Hospital Pediatrics. Volume 15, Issue 2, February 2025. https://doi.org/10.1542/hpeds.2024-007921
•    Rosen, E. et al. (2023). Renal fluid and acid/base balance during refeeding in restrictive eating disorders. International Journal of Eating Disorders, 56(3), 574–581. https://doi-org.online.uchc.edu/10.1002/eat.23873
•    Shook, Jennifer; Brady-Olympia, Jodi. The Inpatient Management of Adolescents with Eating Disorders. Pediatric annals, 2024-08, Vol.53 (8), p.e283-e287

  • Christine Skurkis, MD
  • Alyssa Bennett, MD
  • Lisa Namerow, MD
  • Dakota Michaud, RD

The clinical pathways in the above links have been developed specifically for use at Connecticut Children’s and are made available publicly for informational and/or educational purposes only. The clinical pathways are not intended to be, nor are they, a substitute for individualized professional medical judgment, advice, diagnosis, or treatment. Although Connecticut Children’s makes all efforts to ensure the accuracy of the posted content, Connecticut Children’s makes no warranty of any kind as to the accuracy or completeness of the information or its fitness for use at any particular facility or in any individual case.