Evaluation and Management of Suspected Clostridioides difficile (C. difficile) Infection Clinical Pathway
Clostridioides difficile is a significant infection that is becoming more common in children. Although most episodes can be treated with initial empiric first line therapies, some patients should receive a pre-emptive escalation of therapy. Further, when recurrence becomes an
Skin and Soft Tissue Infection Clinical Pathway
Over the years, the increase in resistance to typical antibiotics has changed the approach to the management of skin and soft tissue infections (SSTIs) in children. In 2014, the Infectious Disease Society of America (IDSA) updated their SSTIs guidelines. Based on these changes
Eating Disorder Clinical Pathway
Eating disorders are increasingly prevalent in pediatrics and represent a complex interaction between medical and psychiatric manifestations. The need for a standardized approach is critical, due to the high risk of the condition (eating disorders have the highest mortality of

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Mastermind Advisor Spotlight: Scott Orsey
Research shows 90% of children’s health is driven by the complex interplay between social, behavioral, environmental, and genetic/epigenetic factors. Connecticut Children’s Childhood Prosperity Lab (the Lab) incubates and accelerates social innovations that address the social

Gastroenterology Research
Connecticut Children’s is among the most active pediatric health systems in the country for basic, clinical and translational research. Our nationally recognized gastroenterologists lead and collaborate on over 25 IRB-approved studies, including NIH- and privately-funded
Neonatology Research
Supported by NIH-funding and other private sources, the Division of Neonatology is improving outcomes and guiding best practices. Our team engages in basic, clinical and translational areas of investigation that include human milk, brain injury and necrotizing enterocolitis (NEC)
Appendicitis Clinical Pathway
Abdominal pain is a common reason for presentation to the Emergency Department, pediatric and surgical offices, and appendicitis is a common surgical etiology for this type of pain. Over the years, the American Pediatric Surgical Association has altered their guidelines for the
High Flow Nasal Cannula Use in Patients Outside of the Intensive Care Unit Clinical Pathway
High flow systems are designed to heat and humidify gas mixtures for safe delivery at flow rates that meet or exceed a patient’s inspiratory flow demands, thereby decreasing work of breathing in the setting of respiratory illness. In addition to the benefits of avoiding more
Craniosynostosis – Minimally Invasive Clinical Pathway
To date, all craniosynostosis patients have been admitted post operatively to the Pediatric Intensive Care Unit (PICU). Currently the majority of these children have minimally invasive craniosynostosis repair. With the minimally invasive surgery blood loss is minimal and there
Status Epilepticus Clinical Pathway
Status epilepticus is a relatively common medical presentation, with 18-41 per 100,000 children presenting to emergency rooms each year. The American Epilepsy Society made recommendations in 2016 for treatment of prolonged seizures, which includes level A evidence of
Suspected Neurosurgical Shunt Infection Clinical Pathway
Ventricular-peritoneal shunt placement is a common neurosurgical procedure. Ventricular-peritoneal shunt infection is a known risk in children with this hardware. Early recognition and treatment is essential to prevent further morbidity, and it also leads to decreased medical
Anaphylaxis Clinical Pathway
Pathway Background and Objectives Anaphylaxis is a multisystem emergency that can progress to a life threatening condition, and therefore requires prompt recognition and treatment. Leading causes of anaphylaxis are medications, foods, and Hymenoptera species (i.e. bees, wasps
Animal and Human Bite Skin and Soft Tissue Infection Clinical Pathway
Animal bites are a common reason for presentation to the Emergency Department and pediatric and surgical offices. The Infectious Diseases Society of America updated their Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections in 2014, and these
Constipation Clinical Pathway
Constipation is a common pediatric diagnosis with wide variation in evaluation and treatment in the acute care setting. This pathway seeks to standardize the diagnosis, evaluation, treatment, and disposition of patients diagnosed with constipation. This pathway utilizes the Rome