Seeking to Prevent NEC Through Novel Microbiome Research
Connecticut Children’s is one of the few hospitals in the nation looking at how microbial metabolites can more directly influence intestinal barrier function and inflammation associated with necrotizing enterocolitis (NEC) in premature infants. Adam Matson, MD, MS, a neonatologist studying the immunologic processes that regulate intestinal health in preemies and full-term infants, is working toward a deeper understanding of the relationship between NEC and a child’s microbiome.
Through his work, he has identified populations of bacteria in the neonatal gut associated with the development of NEC and is determining how these microbes work to disrupt the protective intestinal barrier. He is also investigating how end products produced by beneficial bacteria can optimize intestinal health and prevent this catastrophic disease of prematurity.