To refer a patient to Connecticut Children’s, contact the OneCall team:

COVID-19

Pathway Background and Objective(s)

As confirmed cases of Coronavirus rise in the United States, Connecticut Children’s is taking a proactive approach to prepare for pediatric cases in Connecticut. We are working closely with the Connecticut Department of Public Health and the Centers for Disease Control and Prevention (CDC). At this point in time, there is no evidence that children have a greater risk for COVID-19. The greatest number of reported infections are occurring in the adult population. There have, however, been some reported infections in children, most resulting in minor respiratory infections and flu-like symptoms. No vaccine or specific treatment for COVID-19 is available; care is supportive.

The specific objectives of the COVID-19 clinical pathways are to:

  • Educate community primary care and hospital-based providers on how to evaluate and diagnose patients with a possible COVID-19 infection
  • Understand how to appropriately triage patients with possible COVID-19 infection, including when to send patients to the emergency department
  • Ensure medical staff understand proper isolation and personal protective equipment procedures

Algorithm

COVID-19 Monoclonal Antibody Infusions and Outpatient Therapies

Connecticut Children’s is offering services for the administration of COVID-19 medications. Available therapies may rapidly change depending on circulating variants and drug availability. Please check back often for the latest status.

  • Treatment
    • Remdesivir IV: Now fully FDA approved for those 28 days and older and weighing at least 3 kg. This requires IV treatment, once daily for 3 days, and may be limited to bed availability
    • Paxlovid PO:
      • 12 years and older and weighing at least 40 kg: Patients MUST meet specific EUA criteria in order to qualify. Paxlovid has multiple contraindications and drug interactions. Fact Sheet for Paxlovid
      • If the patient is 0-17 years old, symptomatic (but not hospitalized due to illness), and at risk for progressing to severe disease, the patient may be a candidate for a clinical trial investigating oral paxlovid. Contact Principal Investigator Dr. Hassan El Chebib at HElchebib@connecticutchildrens.org or 860-545-9490.
    • Note: bebtelovimb is no longer effective towards circulating COVID-19 strains, and will no longer be available as of 12/1/2022.
  • Pre-Exposure Prophylaxis
    • Evusheld IM: May not be as effective against current circulating strains (11/2022). Patients MUST meet specific EUA criteria in order to qualify. We have limited doses available. Fact Sheet for Evusheld 

If you believe your patient meets criteria for receiving this infusion and you have reviewed the applicable Fact Sheet for Patients and Caregivers (linked above) with them, please call our OneCall Hotline at 833-226-2362 to obtain approval to infuse at Connecticut Children’s. Specifics can be found here: COVID-19 Outpatient Therapies for Providers Requesting Administration at Connecticut Children’s

Key References

Pathway Contacts

  • John Schreiber, MD
  • Heather Tory, MD
  • Dara Tynan, MD
  • Anand Sekaran, MD
  • Sarah Matney, RN
  • Scott Van Epps, RT
  • Michele McKee, MD
  • Carla Pruden, MD
  • Grace H. Hong, APRN
  • Annmarie Golioto, MD
  • Brett Citarella, MD
  • David Sink, MD
  • Kenneth Banasiak, MD
  • Heather Schlott, MD
  • Jennifer Girotto, PharmD

Disclaimer

The clinical pathways in the above links have been developed specifically for use at Connecticut Children’s and are made available publicly for informational and/or educational purposes only. The clinical pathways are not intended to be, nor are they, a substitute for individualized professional medical judgment, advice, diagnosis, or treatment. Although Connecticut Children’s makes all efforts to ensure the accuracy of the posted content, Connecticut Children’s makes no warranty of any kind as to the accuracy or completeness of the information or its fitness for use at any particular facility or in any individual case.

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