Connecticut Children’s Medical Center’s main campus is located at 282 Washington Street in Hartford, Connecticut.

Institutional Review Board

The Institutional Review Board (IRB) is a committee appointed by Connecticut Children’s Physician-in-Chief, Juan Salazar, MD, our institutional official for the program.

The IRB prospectively reviews the initiation, modification and continuation of research involving human subjects and approves research in accordance with the requirements of the applicable federal, state and local regulations, the Federal Wide Assurance and institutional policies.

Human Subject Research Determination

The responsibility for initial determination as to whether an activity constitutes human subjects research rests with the investigator. This determination should be made based on the definitions of “human subject” and “research” in the HRPP Standard Operating Procedures.

Final determination rests with Connecticut Children’s HRPP. A confirmation that an activity does not constitute human subjects research should be requested by submitting a Human Subject Research Determination form through IRBManager. All requests must include sufficient documentation of the activity to support the determination.

If you have questions or need additional information regarding the human subjects research determination process, please contact the HRPP Director at 860.837.5517.

IRB Review

All human subjects research conducted under the auspices of Connecticut Children’s must meet the criteria for one of the following levels of review:

  • Exempt
  • Expedited review
  • Full board review

Detailed policies and procedures for IRB review are included in the HRPP Standard Operating Procedures.

If you have questions or need clarification regarding the IRB review process, please call the IRB Office at 860.837.5516.

We are surrounded by amazing breakthroughs in medicine every day. There are vaccines that can prevent diseases; there are new surgical techniques that allow operations to be performed through the smallest of incisions, as well as medicines that allow children with chronic illnesses to live healthier lives. While medicine has come a long way, there is still much more that needs to be done. One important way to advance medicine is through clinical research.

Clinical research can help us to understand how medications and therapies affect children. Many new drugs and medical devices go on the market without being tested among children. Despite the lack of research data for children, these therapies become widely used. The US government has offered incentives to manufacturers to conduct clinical trials with children for drugs and devices that have already been approved for adults. These clinical trials can determine whether drugs and treatments are both safe and effective for children.

For children with chronic illnesses, new therapies that are not yet on the market may offer more choices to manage their conditions. For example, new ways of delivering insulin to diabetic children, such as pumps and inhalant devices, were first tested in clinical trials to determine if they worked as well as injected insulin.

Connecticut Children’s Medical Center has a Clinical Trials Unit that helps physicians, nurses and families participate in clinical research studies. The staff of the Clinical Trials Unit has more than 40 years combined experience conducting clinical research and understands the special needs of children and families.

Our physicians and Clinical Trials Unit staff work hand in hand with the assistance of study volunteers – incredible children and their families who are willing to participate in clinical studies that help determine if research ideas hold promise for better treatment, prevention and cures.

Volunteers can be of any age or gender. Studies need both healthy volunteers and children with a specific illness or inherited disorder. Volunteers have diverse cultural, ethnic and racial backgrounds.

To choose to participate in research is an important family decision. Whatever the reason to participate in a research study, each and every research volunteer and his or her family is instrumental in shaping the future of medicine.

Patients who are interested in volunteering to participate in research can learn more by viewing informational videos, brochure, list of questions to ask researchers, and additional resources related to research participation that have been created by the Office for Human Research Protections (OHRP), a federal government agency:

For more information, please see Frequently asked Questions for Families. »

In addition, those considering volunteering for research can review the Belmont Report, which outlines the ethical considerations in research involving human subjects. The report was compiled by the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in 1979, and served as the framework for the federal regulations created to protect human subjects.



If you have any questions or concerns about your role and rights as a research participants, would like to obtain information or offer input, or would like to register a complaint about a specific study, please contact Stacy Chandna, HRPP Director via email or at 860.837.5517.

*Anonymous inquiries are welcomed.

IRBManager is the electronic submission system used at Connecticut Children’s for research involving human subjects. Please contact the IRB/HRPP Office if you need assistance, have questions or to request a consultation regarding IRBManager by calling 860.837.5516. All prospective investigators should note that all IRB submissions must be made through IRBManager. Paper submissions will not be accepted.

IRBManager is a web-based tool and can be accessed from any Internet browser. Please note: IRBManager is NOT accessible through the Hartford Hospital portal or the Connecticut Children’s shared drive.

You will need a username and password to access this system for the first time.  Your password should be kept confidential and not shared with anyone.  Please contact the IRB office to obtain a username and password for IRBManager.  IRB office personnel are available to meet with investigators and research staff  to offer training and assistance in the use of the electronic submission system.

Before beginning an application, please send your study protocol and any data collection tools for scientific review unless your application is for a multi-centered trial and/or an industry sponsored trial. Materials can be emailed to Brenda Labbe, Science Review Committee.

CCMC Institutional Review Board A
2020 Meeting Dates and Deadlines for Submission

Meeting Date
(2nd Monday of month)

Submission Deadline
(3 weeks prior)

Meeting Location
(Meetings start at 4 pm)

 January 6, 2020 December 16, 2019 Conference Room E & F
February 10, 2020 January 20, 2020 Conference Room E & F
March 9, 2020 February 17, 2020 Conference Room E & F
April 13, 2020 March 23, 2020 Conference Room E & F
May 11, 2020 April 20, 2020 Conference Room E & F
June 8, 2020 May 18, 2020 Conference Room E & F
July 13, 2020 June 22, 2020  Conference Room E & F
August 10, 2020 July 20, 2020 Conference Room E & F
September 14, 2020 August 24, 2020 Conference Room E & F
October 5, 2020 September 14, 2020 Conference Room E & F
November 2, 2020 October 12, 2020 Conference Room E & F
 December 14, 2020 November 23, 2020 Conference Room E & F

CCMC Institutional Review Board B
2020 Meeting Dates and Deadlines for Submission

Meeting Date
(4th Monday of month)

Submission Deadline
(3 weeks prior)

Meeting Location
(Meetings start at 4 pm)

January 27, 2020 January 6. 2020 Conference Room E & F
February 24, 2020 February 3, 2020 Conference Room E & F
March 23, 2020 March 2, 2020 Conference Room E & F
 April 27, 2020 April 6, 2020 Conference Room E & F
 May 26, 2020 (Tuesday) May 4, 2020 10 Columbus Blvd, Room 2152
 June 22, 2020 June 1, 2020 Conference Room D
July 27, 2020 July 6, 2020 Conference Room E & F
August 24, 2020 August 3, 2020 Conference Room E & F
September 28, 2020 September 7, 2020 Conference Room E & F
October 26, 2020 October 5, 2020 Conference Room E & F
November 23, 2020 November 2, 2020 Conference Room E & F
December 21, 2020
November 30, 2020 Conference Room E & F

Francis DiMario, MD, CIP
Director, Human Research Protection Program
Chair, Connecticut Children’s Institutional Review Board

Stacy Chandna, MS, CIP
Director, Human Research Protection Program
Vice Chair, Connecticut Children’s Institutional Review Board

Carrie Zevetchin, MS, CIP
IRB Manager, Human Research Protection Program

Jennifer Delgado, MPH, CIP
IRB Systems Analyst, Human Research Protection Program

Taylor Dubreuil, BA
IRB Coordinator, Human Research Protection Program


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