Research Connecticut Children’s is among the most active in the country for basic, clinical and translational research. Our nationally-recognized gastroenterologists lead and collaborate on 32 IRB-approved studies, including NIH- and privately-funded digestive diseases research projects. Connecticut Children’s Department of Gastroenterology is involved in several other research initiatives including: Jeffrey Hyams, MD, along with Lee “Ted” Denson, MD, from Cincinnati Children’s Hospital Medical Center, are Co-Principal Investigators for a $10.4 million NIH grant for the Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT) study. As the hub of the Pediatric Inflammatory Bowel Disease Collaborative Research Group, a 30-member organization formed in 2002, Connecticut Children’s leads ongoing research on the natural history of more than 1,700 cases of newly diagnosed IBD in children, correlating disease behavior with genetic and immunological parameters. Connecticut Children’s is one of 7 vanguard sites in the RISK stratification study funded by the Crohn’s and Colitis Foundation Wael Sayej, MD is investigating basic mechanisms of inflammation in eosinophilic esophagitis and focusing on inflammatory markers and diagnostic testing in eosinophilic esophagitis. Dr. Sayej is also involved in state-of-the-art research on esophageal tissue engineering.